Interestingly, these incretin-sensitising effects of metformin appear to be mediated by a peroxisome proliferator-activated receptor -dependent pathway, as opposed to the more commonly ascribed pathway of metformin action involving AMP-activated protein kinase
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thoracic sympathectomy is a surgical cure but has risks like compensatory sweating
Fluorescence was viewed using a charge-coupled device camera (DP72, Olympus, Melville, NY, USA) attached to a microscope system (BX51, Olympus) at 100 magnification
N Engl J Med 373(22):21172128